At the core of HSSRF's mission in bridging the gap, HSSRF is dedicated to conducting quality research that will provide evidence to improve health. Through a multi-disciplinary approach, HSSRF aims to generate valuable insights and evidence to inform policy and practice, aiming to improve health outcomes and social conditions throughout the country.

HSSRF’s research focuses on several key areas, including public health, social determinants of health, health systems research, and behavioral sciences. The foundation adheres to rigorous research methodologies and collaborates with leading institutions to ensure the quality and credibility of its findings. Additionally, the foundation works closely with stakeholders to ensure that its research is implemented in real-world settings to improve health and social well-being in Tanzania.